Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis. (Article, 2010) [Beloit College]
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Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis.

Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis.

Author: Y Shi Affiliation: Department of Immunology and Laboratory Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang, China.H WangZ SuJ ChenY XueAll authors
Edition/Format: Article Article : English
Publication:Scandinavian journal of immunology, v72 n3 (201009): 250-5
  Peer-reviewed
Other Databases: WorldCatWorldCatWorldCat
Summary:
T helper 17(Th17) cell is a new subset of CD4(+) T cells that produce a proinflammatory cytokine interleukin-17 (IL-17). Th17 cells have recently been shown to play a critical role in many autoimmune diseases that had previously been thought to be Th1 dominant. Although Hashimoto's thyroiditis (HT) was thought to be a Th1-type disease, the contributions of Th17 cells to the pathogenesis remain unclear. In this  Read more...
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Details

Document Type: Article
All Authors / Contributors: Y Shi Affiliation: Department of Immunology and Laboratory Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang, China.; H Wang; Z Su; J Chen; Y Xue; S Wang; Y Xue; Z He; H Yang; C Zhou; F Kong; Y Liu; P Yang; L Lu; Q Shao; X Huang; H Xu
ISSN:0300-9475
DOI: 10.1111/j.1365-3083.2010.02425.x
Language Note: English
Unique Identifier: 672383881
Awards:

Abstract:

T helper 17(Th17) cell is a new subset of CD4(+) T cells that produce a proinflammatory cytokine interleukin-17 (IL-17). Th17 cells have recently been shown to play a critical role in many autoimmune diseases that had previously been thought to be Th1 dominant. Although Hashimoto's thyroiditis (HT) was thought to be a Th1-type disease, the contributions of Th17 cells to the pathogenesis remain unclear. In this study, we investigated the expression levels of Th1/Th17 cell-associated factors in peripheral blood mononuclear cells (PBMC) and plasma from patients with HT by quantitative real-time polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA). Our results showed that the expression levels of Th1 cells-related T-bet and interferon-gamma (IFN-gamma) mRNA in PBMC from HT significantly decreased. However, the mRNA of Th17 coherent retinoic acid-related orphan nuclear receptor gamma t (RORgammat) and IL-17 in patients with HT increased. In addition, a negative correlation between T-bet and RORgammat mRNA expression was found in patients with HT, and the similar phenomena also appeared on the levels of mRNA and plasma concentration between IFN-gamma and IL-17. It suggested that Th17 cells rather than Th1 cells predominated among patients suffering from HT, and Th17 cells might be involved in the pathogenesis of HT.
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