Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger. (Article, 2006) [Beloit College]
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Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Author: Igor A Parshikov Affiliation: Department of Medicinal Chemistry, University of Mississippi, University, MS 38677, USA.; Brushapathy Miriyala; Kannoth M Muraleedharan; Mitchell A Avery; John S Williamson
Edition/Format: Article Article : English
Publication:Journal of industrial microbiology & biotechnology, v33 n5 (200605): 349-52
  Peer-reviewed
Other Databases: Academic Search CompleteWorldCat
Summary:
Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance.  Read more...
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Details

Document Type: Article
All Authors / Contributors: Igor A Parshikov Affiliation: Department of Medicinal Chemistry, University of Mississippi, University, MS 38677, USA.; Brushapathy Miriyala; Kannoth M Muraleedharan; Mitchell A Avery; John S Williamson
ISSN:1367-5435
Language Note: English
Unique Identifier: 110513377
Awards:

Abstract:

Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. 5Beta-hydroxyartemisinin and 7beta-hydroxyartemisinin were isolated in 63 and 32% yields, respectively, from the extract of E. amstelodami, and 80 and 19%, respectively, from the extract of A. niger.
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You can found more in book of Igor A. Parshikov ISBN 978-1-68419-775-0

by igorcen (WorldCat user published 2016-07-19) Excellent Permalink

You can found more in book:

Igor A. Parshikov. Microorganisms in Chemistry of Terpenoids. – Dallas: Primedia E-launch LLC, 2016. − 102 p. IBSN 978-1-68419-775-0

Links:

http://www.bookwire.com/book/USA/Microorganisms-in-Chemistry-of-Terpenoids-9781684197750-Parshikov-Igor-A-56140330

https://openlibrary.org/people/igorcen/lists/OL99679L/Back_in_Science

 

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