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  E-mail Message: I thought you might be interested in this item at http://beloit.worldcat.org/oclc/110513377 Title: Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger. Publisher: ISBN/ISSN: 1367-5435 OCLC:110513377

  
  

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Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Author:	Igor A Parshikov Affiliation: Department of Medicinal Chemistry, University of Mississippi, University, MS 38677, USA.; Brushapathy Miriyala; Kannoth M Muraleedharan; Mitchell A Avery; John S Williamson
Edition/Format:	Article : English
Publication:	Journal of industrial microbiology & biotechnology, v33 n5 (200605): 349-52
	Peer-reviewed
Other Databases:	Academic Search Complete; WorldCat
Summary:	Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. 5Beta-hydroxyartemisinin and 7beta-hydroxyartemisinin were isolated in 63 and 32% yields, respectively, from the extract of E. amstelodami, and 80 and 19%, respectively, from the extract of A. niger.  Read more...
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